Exploring the capacity of Homer and other rare gene variants and the critical part they play in human function.

What is Homer Hack?

The Homer Hack is a Not For Profit Charity holding a DGR 1 status. It consists of a broad group of individuals who have a keen joint interest in the effects of Homer gene variants and other scaffolding genes in humans on day-to-day function. Some members have been personally touched by the debilitating effects of Homer gene variants whilst others have scientific interests in research discoveries and translating results into tangible outcomes. The team donates their time, energy, and resources to this worthwhile cause in the hope of benefiting many families in the future.

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What we know

Many neurological disorders are thought to be conditions of altered neuronal connectivity. There is now increasing recognition of the importance of rare, de novo variants as contributors to disease risk and as targets for investigation of the disrupted cellular mechanisms which can be implicated in neuronal connectivity disorders such as Autism, Bipolar Disorder, Schizophrenia, and Depression. Genomic studies have now been able to identify gene variants in scaffolding proteins as key contributors underpinning these disorders.

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Our goals

The main aim of Homer Hack is to increase awareness of the effects of rare gene variants in scaffolding genes such as Homer. We aim to involve people in this journey in the hope of securing greater funds to contribute to neuroscience and neurological research endeavours. We hope to see these scientific and medical breakthroughs translated into developing greater insight into therapeutic approaches for disease management of a broad range of neurodevelopmental conditions.

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D’Arne Finnis
The Homer Hacker - Founder

Associate Professor Libby Callaway
The Homer Hack - Team Member

A study of the function of Homer1 in synaptogenesis

"Our aspirations are to increase awareness in the general population of Homer and other rare gene variants and their effects on the developing nervous system and contribution to complex neurological conditions including autism, bipolar disorder, and schizophrenia. By increasing funding, we hope to expedite research and evidence to assist families with faster diagnosis timeframes. Finally - and most importantly - we aim to connect people with these rare gene variants and their families with others to provide support and guidance on the treatment journey and improve long-term outcomes..”

— D’Arne Finnis, The Homer Hack Founder